Boswellia is used for:
Photochemical: One of the principal constituents in the gum resin is boswellic acid, which exhibits anti-inflammatory activity.
A purified compound of the boswellia is marketed in India with the brand name Sallaki. Many studies conducted since the original study has confirmed that Boswellia serrata has potent anti-inflammatory and anti-arthritic activity.
Boswellia, also known as Shallaki or Boswellia serrata is a natural and safe herb for optimum joint health. It has traditionally been used as incense because of its fragrant properties. One active constituent, Boswellic Acid, is a pyrazoline derivative shown to be very effective in supporting healthy joints. Like its cousin Guggul, Boswellia has many cholesterol and triglyceride lowering properties. One of the principal constituents in the gum resin is boswellic acid which exhibits anti-inflammatory activity.
Boswellia has been used extensively in Ayurveda for joint support and to provide an overall sense of well-being. Also known as "Salai Guggul," it is like its cousin Guggul in offering broad health and immunomodulating benefits. The gum resin is used as an ointment for sores and has anti-inflammatory, antiatherosclerotic and antiarthritic activities. The nonphenolic fraction of the gum resin had marked sedative and analgesic action. The gum is a well known household fumigant and is used as an anti-inflammatory agent when applied externally. Internally, besides being antiarthritic, it has expectorant effects. It also reduces body weight.
In clinical trials, promising results were observed in patients with rheumatoid arthritis, chronic colitis, ulcerative colitis, Crohn's disease, bronchial asthma und peritumoral brains edemas. Boswellic acids inhibit the leukotriene biosynthesis in neutrophilic granulocytes by a non-redox, noncompetitive inhibition of 5-lipoxygenase. The effect is triggered by boswellic acids binding to the enzyme. Moreover certain boswellic acids have been described to inhibit elastase in leukocytes, to inhibit proliferation, induce apoptosis and to inhibit topoisomerases of leukoma- and glioma cell lines. A series of chronic inflammatory diseases are thought to be perpetuated by leukotrienes.
Use of Shallaki in arthritis
In clinical and preclinical studies, Boswellia serrata has been shown to contribute potent anti-inflammatory activity. Boswellic acids exert anti-inflammatory response by preventing leukotriene synthesis. During pharmacological evaluation the extract of Boswellia serrata in experimental animals, displayed marked anti-inflammatory activity in various models like carrageenan-induced oedema in rats and mice and dextran oedema in rats. Two placebo-controlled studies, involving a total of 81 individuals with rheumatoid arthritis, found significant reductions in swelling and pain over the course of 3 months. A comparative study in 60 arthritic patients over 6 months showed that Boswellia extract produced symptomatic benefits comparable to oral gold therapy in arthritic patients. According to a recent review of unpublished studies, preliminary double-blind trials have found Boswellia to be effective in relieving the symptoms of rheumatoid arthritis